National Advisory Committee on Immunization (NACI) recommends SHINGRIX for the prevention of shingles for adults aged 50 and up
MISSISSAUGA, ON – The National Advisory Committee on Immunization (NACI) has made a strong recommendation for SHINGRIX, GSK’s vaccine for the prevention of shingles. NACI recommends SHINGRIX should be offered to individuals 50 years of age and older without contraindications. Further, NACI indicates a strong recommendation should be followed unless there is a clear and compelling rationale for an alternative approach.i
Shingles is caused by reactivation of the varicella zoster virus (VZV), the same virus that causes chickenpox.ii More than 90 percent of those over 50 years old have had chickenpox and are at risk for shingles. A person’s risk for shingles increases with age and an estimated 30% of Canadians will develop shingles in their lifetime.iii,iv,v
Dr Susie Barnes, Vice President and Country Medical Director, GSK Canada said: “After the age of 50 a person’s risk for shingles increases. With approximately 130,000 new cases of shingles each year in Canada, the NACI recommendation is an important step forward for prevention of the disease among older Canadian adults.”
SHINGRIX is indicated for the prevention of shingles (herpes zoster) in people aged 50 years or older.vi
Shingles is caused by varicella zoster virus (VZV), the same virus that causes chickenpox.ii
Shingles typically presents as a rash, with painful blisters across the chest, abdomen or face. The pain is often described as aching, burning, stabbing or shock-like. Following the rash, a person can also experience post-herpetic neuralgia (PHN), pain that can last for months or years.ii PHN is the most common complication of shingles, occurring in up to 30 percent of all shingles cases.vii
Shingles affects an estimated 130,000 Canadians annually.v Incidence rates are similar throughout North America, Europe and Asia-Pacific regions.vii Older adults and those with conditions that compromise the immune system have the greatest risk for developing shingles. Nearly all adult Canadians (≥90%) have had chickenpox and are therefore at risk for shingles. An estimated 30% will develop shingles in their lifetime and the risk increases to 50% for those who live to 85 years of age.ii
SHINGRIX [Herpes Zoster vaccine (non-live recombinant, AS01B adjuvanted)] is a non-live, recombinant subunit adjuvanted vaccine to help prevent herpes zoster (shingles) in adults 50 years of age and older. The vaccine is to be given intramuscularly in two doses with a two-to-six month interval between doses and combines an antigen (VZV glycoprotein E) and an adjuvant system (AS01B).viii
The Product Monograph, posted at www.ca.gsk.com, should be consulted for complete administration and safety information.
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- National Advisory Committee on Immunization (NACI). Updated Recommendations on the Use of Herpes Zoster Vaccines. Public Health Agency of Canada, June 2018.
- Harpaz R, Ortega-Sanchez IR, Seward JF; Advisory Committee on Immunization Practices (ACIP), Centers for Disease Control and Prevention (CDC). MMWR Recomm Rep. 2008 Jun;57(RR-5):1-30. Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices.
- National Advisory Committee on Immunization (NACI). Statement on the Recommended use of Herpes Zoster Vaccine. January 2010, 36(ASC-1):1-19.
- Brisson, M, et al. Modelling the impact of immunization on the epidemiology of varicella zoster virus. Epidemiol. Infect. 2000; 125, 651-669.
- Canadian Immunization Guide: Part 4 – Active Vaccines, Herpes Zoster (Shingles) Vaccine. Last updated March 2014. Accessed June 1, 2018. http://healthycanadians.gc.ca/publications/healthy-living-vie-saine/4-canadian-immunization-guide-canadien-immunisation/index-eng.php?page=8
- SHINGRIX Canadian Product Monograph, October 2017.
- Kawai, et al. BMJ Open. 2014; 4(6). Systematic review of incidence and complications of herpes zoster: towards a global perspective.
- The GSK proprietary AS01 adjuvant system contains QS-21 Stimulon® adjuvant licensed from Antigenics LLC, a wholly owned subsidiary of Agenus Inc. (NASDAQ: AGEN), MPL and liposomes.